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PSA, Total with Reflex to PSA, Free
Test Code17569
CPT Codes
84153
Includes
If Total PSA is between 4.0-10.0 ng/mL, then Free PSA will be performed at an additional charge (CPT code(s): 84154).
Preferred Specimen
2 mL frozen serum collected in an SST (red-top) tube
Minimum Volume
0.6 mL
Instructions
Do not collect specimen after a transrectal biopsy, results may be falsely elevated.
Administration of STRENSIQ may interfere in certain assays and may falsely elevate values. For patients receiving STRENSIQ, consideration should be given to using alternate methods.
Administration of STRENSIQ may interfere in certain assays and may falsely elevate values. For patients receiving STRENSIQ, consideration should be given to using alternate methods.
Transport Temperature
Frozen
Specimen Stability
Room temperature: 72 hours
Refrigerated: 72 hours
Frozen: 5 months
Refrigerated: 72 hours
Frozen: 5 months
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Daily; Report available: 1-2 days
Clinical Significance
In men over 50 years with Total PSA between 4.0 and 10.0 ng/mL, the percent (%) Free PSA gives an estimate of the probability of cancer. In these circumstances the measurement of the % Free PSA may aid in avoiding unnecessary biopsies.
Elevated levels of prostate specific antigen (PSA) have been associated with benign and malignant prostatic disorders. Studies indicate that in men 50 years or older measurement of PSA is a useful addition to the digital rectal exam in the early detection of prostate cancer. In addition, PSA decreases to undetectable levels following complete resection of the tumor and may rise again with recurrent disease or persist with residual disease. Thus, PSA levels may be of assistance in the management of prostate cancer patients.
Elevated levels of prostate specific antigen (PSA) have been associated with benign and malignant prostatic disorders. Studies indicate that in men 50 years or older measurement of PSA is a useful addition to the digital rectal exam in the early detection of prostate cancer. In addition, PSA decreases to undetectable levels following complete resection of the tumor and may rise again with recurrent disease or persist with residual disease. Thus, PSA levels may be of assistance in the management of prostate cancer patients.
