Copper, Liver Tissue

Test Code

13241

CPT Codes
82525

Preferred Specimen

2 cm liver tissue in royal blue trace metal free tube

Patient Preparation
Gadolinium is known to interfere with most metal tests. If gadolinium-containing contrast media has been administered a specimen should not be collected for 96 hours.

Minimum Volume

Liver tissue: 1 cm
Fixed tissue: 2 mg

Other Acceptable Specimens

2 mg tissue in paraffin block if no more than 1 or 2 cuts have been made to it for slides

Instructions

1. Two mg of liver tissue is required. This is typically a piece of tissue from a 22-gauge needle biopsy at least 2 cm long. If an 18-gauge needle is used, the tissue must be at least 1 cm in length.
2. Any specimen vial other than a Mayo metal-free vial used should be plastic, leached with 10% nitric acid for 2 days, rinsed with redistilled water, and dried in clean air.

Additional information: Paraffin blocks will be returned 3 days after analysis is complete.

Acceptable: 2 mg tissue in paraffin block if no more than 1 or 2 cuts have been made to it for slides.

Gadolinium is known to interfere with most metal tests. If gadolinium-containing contrast media has been administered a specimen should not be collected for 96 hours.

Transport Temperature

Liver tissue: Refrigerated (cold packs)
Fixed tissue: Room temperature

Specimen Stability

Liver tissue
Room temperature: Unacceptable
Refrigerated: 10 days
Frozen: Unacceptable

Fixed tissue
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Indefinite

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability

Methodology
Inductively Coupled Plasma-Mass Spectrometry

Setup Schedule

Sets up 2 days a week.

Clinical Significance

Diagnosing Wilson disease and primary biliary cirrhosis
using liver tissue specimens.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.