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L-Glycerate, Urine with Creatinine
Test Code12731
CPT Codes
82542, 82570
Preferred Specimen
5 mL urine with no preservative collected in a plastic urine container
Minimum Volume
1 mL
Other Acceptable Specimens
Urine acidified with 6N HCL collected in a plastic urine container
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 72 hours
Frozen: 30 days
Refrigerated: 72 hours
Frozen: 30 days
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
A.M. Sets up 1 day a week.
Clinical Significance
The primary hyperoxalurias (PH) are a group of inherited disorders caused by defects in glyoxylate metabolism, with a combined incidence of about 1:60,000. To date, three primary hyperoxalurias have been described, designated as PH1, PH2, and PH3. All three forms follow an autosomal recessive mode of inheritance, and lead to increased oxalate levels in the body. The typical presentation is with recurring calcium oxalate renal stones. Calcium oxalate can also deposit in various tissues including the kidneys (nephrocalcinosis). End stage renal disease can occur from damage caused by the systemic oxalosis. The age of onset of symptoms ranges from infancy to adulthood; some adults may remain asymptomatic until the sixth decade.
