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HIV-1 RESISTANCE
Test CodeLAB948007
Preferred Specimen
2 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
0.6 mL
Transport Container
EDTA (lavender-top) tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Refrigerated: 7 days
Frozen: 28 days
Methodology
Polymerase Chain Reaction (PCR) • Next Generation (ultra-deep) Sequencing
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Tues, Sat
Report Available
5-8 days
Clinical Significance
This test utilizes PCR and next generation (ultra-deep) sequencing of proviral DNA to detect drug resistance mutations in the HIV-1 protease, reverse transcriptase and integrase genes. This information will assist clinicians considering a modification of the treatment regimens for virologically suppressed patients or for patients with a low viral load for whom an RNA resistance test was not successful.
