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Soluble Liver Antigen (SLA) Autoantibody
Test Code38928
Preferred Specimen
1 mL serum
Minimum Volume
0.3 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 8 days
Frozen: 28 days
Refrigerated: 8 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Lipemia
Methodology
Immunoassay (IA)
Setup Schedule
A.M. Sets up 1 day a week.
Clinical Significance
Anti-soluble liver antigen antibodies are detected in 10-30% of patients with type 1 autoimmune hepatitis (AIH), but not in patients with type 2 AIH, primary sclerosing cholangitis or primary biliary cirrhosis. The antibody is directed against a UGA suppressor tRNA-associated protein. In some patients with AIH, this antibody may be the only autoantibody detected by current assays.