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Thrombotic Marker Panel
Test Code11345
Includes
D-Dimer, Quantitative
Fibrin Monomer
Prothrombin Fragment 1.2
Thrombin- Antithrombin (TAT) Complex
Fibrin Monomer
Prothrombin Fragment 1.2
Thrombin- Antithrombin (TAT) Complex
Preferred Specimen
2 mL frozen platelet-poor plasma collected in each of three separate 3.2% sodium citrate (light blue-top) tubes
Minimum Volume
1 mL each specimen
Instructions
Please submit a separate, frozen vial for each special coagulation assay ordered. Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times. Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). Freeze immediately and transport on dry ice.
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 21 days
Refrigerated: Unacceptable
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Received refrigerated • Received room temperature
Methodology
Enzyme Immunoassay (EIA) • Enzyme Linked Immunosorbent Assay (ELISA) • Hemagglutination (HA) • Immunoturbidimetric
Setup Schedule
See individual assays
Clinical Significance
When intravascular thrombosis is suspected in the absence of overt clinical symptoms, elevation in D-dimer, fibrin monomer, prothrombin fragment 1.2, or thrombin-antithrombin complex may be the only indicator of intravascular clot formation and generation of activated factor X. Marked elevation in only 1 or 2 of these markers should lead to further investigation of the site of the thrombosis (eg, early dissecting aortic aneurysm, anomalous arterial/venous fistula).