Liver Fibrosis, FibroTest-ActiTest Panel

Test Code

Quest Code

Alias/See Also

CPT Codes

Fibrosis Score, Fibrosis Stage, Fibrosis Interpretation
Necroinflammat Act Score, Necroinflammat Act Grade, Necroinflammat Interpretation
Apolipoprotein A1
Total Bilirubin

Preferred Specimen
3.5 mL serum

Patient Preparation
Overnight fasting is preferred

Minimum Volume
2 mL

Serum should be separated from the cells as soon as possible after visible clot formation (usually 15-30 minutes after collection). Avoid freezing and thawing.

Transport Temperature

Specimen Stability
Room temperature: 24 hours
Refrigerated: 72 hours
Frozen -20° C: 5 days
Frozen -70° C: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Patients <2 years old • QNS for one or more analytes

Nephelometry • Spectrophotometry (SP)

FDA Status
The performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. Performance characteristics refer to the analytical performance of the test.

Setup Schedule

Reference Range
See Laboratory Report

Clinical Significance
FibroTest and ActiTest permit the non-invasive evaluation of Hepatitis C (or B) individuals for the presence of liver fibrosis and liver inflammation, respectively. The FibroTest and ActiTest scores are calculated based on patient age, gender and concentrations of serum of y-glutamyl transferase (GGT), total bilirubin (TB), a-2 macroglobulin, haptoglobin, apolipoprotein A1 and alanine aminotransferase (ActiTest). Fibrotest and ActiTest Scores, on a scale of 0.0 to 1.0, are assigned a Metavir scale indicating the level of fibrosis or inflammation present.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.