Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM)

Performed at QNI
Test Codes 30340X, 90043N

Test Code

Quest Code

Alias/See Also
30340X, 90043N

CPT Codes
86146 (x3)

Preferred Specimen

3 mL plasma collected in a 3.2% sodium citrate (light blue-top) tube

Minimum Volume
1.5 mL

Other Acceptable Specimens

Plasma: Centrifuge light blue-top tube 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcL).

Transport Temperature

Specimen Stability

Room temperature: 5 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic

Immunoassay (IA)

Setup Schedule
Set up: Mon-Sat

Report Available
Report available: 4-6 days

Factor VIII inhibitors may cause a false-positive lupus anticoagulation test. The temporary presence of antiphospholipid antibodies may accompany infections or certain drugs.

Reference Range
B2-Glycoprotein I (IgG) Ab <20 U/mL Antibody not detected
≥20 U/mL Antibody detected
B2-Glycoprotein I (IgA) Ab <20 U/mL Antibody not detected
≥20 U/mL Antibody detected
B2-Glycoprotein I (IgM) Ab <20 U/mL Antibody not detected
≥20 U/mL Antibody detected

Clinical Significance
Beta-2-Glycoprotein 1 (also known as apolipoprotein H), is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. The presence of high titer IgG/IgM beta-2-glycoprotein 1 antibodies is one criteria for the diagnosis of antiphospholipid antibody syndrome.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.