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Imipramine
Test Code887
CPT Codes
80335 (HCPCS: G0480)
Includes
Imipramine, Desipramine and Total
Preferred Specimen
3 mL serum collected in a red-top tube (no gel)
Patient Preparation
Collect at steady-state trough concentration. Specimen should be collected >12 hours after dose.
Minimum Volume
1.5 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top), sodium heparin (green-top) or lithium heparin (green-top) tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 5 days
Refrigerated: 5 days
Frozen: 30 days
Refrigerated: 5 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Gel barrier/Serum Separator Tube (SST®) • ACD Plasma
Methodology
Chromatography/Mass Spectrometry
Setup Schedule
Set up: Tue-Sat; Report available: 2-4 days
Report Available
2 to 4 Day(s)
Clinical Significance
Imipramine is a tricyclic antidepressant drug used to treat depression. Therapeutic drug monitoring is used to optimize dose and to avoid toxicity.