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Herpes Simplex Virus 1/2 Antibody (IgM), IFA with Reflex to Titer, Serum
Test Code90849
CPT Codes
86695, 86696
Includes
If HSV 1 IgM screen is positive, HSV 1 IgM Titer will be performed at an additional charge (CPT code(s): 86695).
If HSV 2 IgM Screen is positive, HSV 2 IgM Titer will be performed at an additional charge (CPT code(s): 86696).
If HSV 2 IgM Screen is positive, HSV 2 IgM Titer will be performed at an additional charge (CPT code(s): 86696).
Preferred Specimen
1 mL serum
Minimum Volume
0.3 mL
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 60 days
Refrigerated: 14 days
Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Cord blood
Methodology
Immunofluorescence Assay (IFA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Mon-Sat
Report Available
1 to 3 Day(s)
Clinical Significance
HSV IgM is detectable in serum from >90% of patients with primary HSV infection. However, HSV IgM cannot be reliably used to diagnose acute/recent infection as it is also found in 30% of patients with reactivated HSV. This test may not distinguish between HSV-1 IgM and HSV-2 IgM due to cross-reactivity. To diagnose acute genital or mucosal HSV infection, direct detection from a lesion by culture or molecular methods is preferred. HSV IgM positivity should be confirmed by HSV-1/2 type-specific IgG testing.
