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Mitochondria M2 Antibody (IgG), EIA
Test Code1101
CPT Codes
83520
Preferred Specimen
1 mL serum
Minimum Volume
0.3 mL
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Tues, Thurs, Sat; Report available: 1-4 days
Report Available
1 to 3 Day(s)
Clinical Significance
Anti-Mitochondrial antibodies (AMA) have been reported in greater than 90% of patients with Primary Biliary Cirrhosis (PBC). AMA are also occasionally found in patients with chronic active hepatitis, cryptogenic cirrhosis and in patients with clinical but no biochemical evidence of liver disease. The M2 type of AMA is strongly associated with PBC.
Note: The MIT3 antigen used for detection of anti-mitochondria M2 antibodies contains immunodominant epitopes of the E2 subunits of the pyruvate dehydrogenase complex (PDC-E2), the branched-chain 2-oxo-acid dehydrogenase complex (BCOADC-E2), and the 2-oxo glutarate dehydrogenase complex (OGDC-E2).
Reference - Moteki, S. et al. Use of a designer triple expression hybrid clone for three different lipoyl domain for the detection of antimitochondrial autoantibodies. Hepatology 1996; 24:97-103.
Note: The MIT3 antigen used for detection of anti-mitochondria M2 antibodies contains immunodominant epitopes of the E2 subunits of the pyruvate dehydrogenase complex (PDC-E2), the branched-chain 2-oxo-acid dehydrogenase complex (BCOADC-E2), and the 2-oxo glutarate dehydrogenase complex (OGDC-E2).
Reference - Moteki, S. et al. Use of a designer triple expression hybrid clone for three different lipoyl domain for the detection of antimitochondrial autoantibodies. Hepatology 1996; 24:97-103.
