HEPARIN INDUCED PLATELET ANTIBODY

Test Code
LAB1751


Quest Code
414


CPT Codes
86022

Preferred Specimen
1 mL frozen serum collected in a red-top tube (no gel)


Minimum Volume
0.5 mL


Other Acceptable Specimens
Plasma collected in: 3.2% sodium citrate (light blue-top) tube


Instructions
Serum (preferred): Centrifuge red top tube 15 minutes at approximately 1500 g as soon as possible after clotting.
Plasma (acceptable): Centrifuge blue top tube 20 minutes at approximately 2500 g. Remove plasma from the cells as soon as possible.


Transport Container
Transport tube


Transport Temperature
Frozen


Specimen Stability

Room temperature: Unacceptable
Rrefrigerated: Unacceptable
Frozen: 6 months



Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Lipemia • Received room temperature • Received refrigerated • Icteric • Serum separator tube (SST)


Methodology
Immunoassay (IA)

Setup Schedule
Mon-Fri: a.m. and p.m.; Sat, Sun: a.m. Daily


Report Available
2 days


Limitations
When heparin is stopped, antibody that may have been present disappears within weeks to months.


Reference Range
Heparin-Induced Platelet AntibodyNegative
Patient O.D.≤0.300 OD Units


Clinical Significance

Heparin can induce thrombocytopenia, a decreased platelet count, due to antibody stimulation. False positive results may be due to immune complexes. False negative results may be due to low titer, low avidity antibodies.



Performing Laboratory
Quest Diagnostics Nichols Institute-Chantilly VA
14225 Newbrook Drive
Chantilly , VA 20151-2228



Last Updated: August 13, 2021


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.