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Mycophenolic Acid, LC/MS/MS : 10662
Test CodeMYCOA or 10662
CPT Codes
80180
Includes
Mycophenolic Acid and MPA Glucuronide
Instructions
Optimum time to collect sample: 1/2 hour to 1 hour before next dose (trough) at steady-state (3-5 days after treatment with oral doses)
Transport Container
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Alternative Specimens
Plasma collected in: Sodium heparin (green-top) tube or EDTA (lavender-top) tube
Minimum Volume
0.5 mL
Collection Instructions
Serum: Collect blood in plain red-top (no gel) tube. Allow blood to clot at 15-28°C for 20-30 minutes. Centrifuge at 20-25°C (2200-2500 rpm, 1000 x g) for 8-10 minutes. Transfer serum to polypropylene or polyethylene transport tube. Ship refrigerated (cold packs). Samples left at room temperature for more than 3 days are not acceptable.
Plasma: Draw blood into EDTA lavender-top tube. Separate cells by centrifugation at 18-25°C (2500-2800 rpm) for 5-10 minutes. Transfer plasma to polypropylene or polyethylene transport tube. Ship refrigerated (cold packs). Samples left at room temperature for more than 3 days are not acceptable.
1 mL serum collected in a red-top tube (no gel)
Alternative Specimens
Plasma collected in: Sodium heparin (green-top) tube or EDTA (lavender-top) tube
Minimum Volume
0.5 mL
Collection Instructions
Serum: Collect blood in plain red-top (no gel) tube. Allow blood to clot at 15-28°C for 20-30 minutes. Centrifuge at 20-25°C (2200-2500 rpm, 1000 x g) for 8-10 minutes. Transfer serum to polypropylene or polyethylene transport tube. Ship refrigerated (cold packs). Samples left at room temperature for more than 3 days are not acceptable.
Plasma: Draw blood into EDTA lavender-top tube. Separate cells by centrifugation at 18-25°C (2500-2800 rpm) for 5-10 minutes. Transfer plasma to polypropylene or polyethylene transport tube. Ship refrigerated (cold packs). Samples left at room temperature for more than 3 days are not acceptable.
Transport Temperature
Refrigerated.
Specimen Stability
Room temperature: 72 hours; Refrigerated: 14 days; Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis. Lipemia. Specimens left at room temperature greater than 72 hours. Gel barrier/Serum Separator Tube (SST)
Methodology
Chromatography/Mass Spectrometry
Setup Schedule
Monday - Saturday
Report Available
3 days (From receipt at performing laboratory)
Limitations
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Reference Range
Mycophenolic Acid 1.0-3.5 mcg/mL
MPA Glucuronide 35.0-100.0 mcg/mL
MPA Glucuronide 35.0-100.0 mcg/mL
Clinical Significance
Mycophenolic acid is an immunosuppressant used in tissue transplants. It prevents graft rejection by the host's immune system. It is very important to monitor its level. Too little of this drug will cause graft rejection, while too much will lead to infection. Monitoring its level is essential to optimize therapeutic effects, avoid toxicity, and assure compliance.
Performing Laboratory
Quest Diagnostics
