Sirolimus, LC/MS/MS : 1000856

Test Code
SIROLQ or 1000856

Alias/See Also
Rapamune; Rapamycin

CPT Codes
80195

Instructions
Collect specimen 1 hour prior to next dose (12 hour trough)

Lavender (EDTA).

Transport Container
Transport 2 mL whole blood. (Min: 1 mL).

Transport Temperature
Refrigerated.

Specimen Stability
Ambient: 5 days; Refrigerated: 7 days; Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted Specimen

Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Setup Schedule
Monday - Saturday

Report Available
1-2 days (From receipt at performing laboratory)

Reference Range
3.0-18.0 ng/mL

Clinical Significance
Sirolimus is an immunosuppressant drug used to prevent organ graft rejection. Therapeutic drug monitoring is used to optimize dose and avoid toxicity. Peak concentrations are reached in 2 hours following oral administration. Elimination half-life in males is approximately 72 hours; in females approximately 61 hours.

Performing Laboratory
Quest Diagnostics



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.