Acetylcholine Receptor Antibody Reflexive Panel : 1002428

Test Code
ACRABR or 1002428

Alias/See Also
Myasthenia Gravis Antibodies (Acetylcholine Receptor Antibody Reflex Panel)

CPT Codes
83519, 83516

Includes
If Acetylcholine Receptor Binding Antibody result is greater than 0.4 nmol/L, or Acetylcholine Receptor Blocking Antibody result is greater than 15%, then Acetylcholine Receptor Modulating Antibody (Test code 1002393 AMODAB) will be performed at an additional charge (CPT code(s): 83516).

Instructions
Serum separator tube.

Transport Container
Centrifuge serum separator tube ASAP or within 2 hours of collection and transport, 1 mL serum (Min: 0.5 mL).

Transport Temperature
Refrigerated.

Specimen Stability
After separation from cells: Ambient: 2 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid multiple freeze/thaw cycles)

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Severely lipemic, contaminated, or hemolyzed specimens.

Methodology
Quantitative Radioimmunoassay/Semi-Quantitative Flow Cytometry

Setup Schedule
Sunday - Saturday

Report Available
3-7 days (From receipt at performing laboratory)

Limitations
Approximately 10-15% of individuals with confirmed myasthenia gravis have no measurable binding, blocking, or modulating antibodies.

This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Reference Range
Effective November 18, 2013
Acetylcholine Receptor Binding Antibody
Negative: 0.0-0.4 nmol/L
Positive: 0.5 nmol/L or greater

Acetylcholine Receptor Blocking Antibody:
Negative: 0-26% blocking
Indeterminate: 27-41% blocking
Positive: 42% or greater blocking

Acetylcholine Receptor Modulating Antibody
Negative: 0-45% modulating
Positive: 46% or greater modulating

Performing Laboratory
ARUP Laboratories



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.