Acetylcholine Receptor Antibodies and Striated Muscle Antibody Reflexive Panels, and Titin Antibody : 1003566

Test Code
ACRABT or 1003566

Alias/See Also
Myasthenia Gravis (Acetylcholine Receptor Antibodies and Striated Muscle); Myasthenia Gravis/Thymoma (Acetylcholine Receptor Antibodies and Striated Muscle)

CPT Codes
83519; 83516 x2; 86255

Includes
If Acetylcholine Receptor Binding Antibody result is greater than 0.4 nmol/L or Acetylcholine Receptor Blocking Antibody result is greater than 15 percent, then Acetylcholine Receptor Modulating Antibody (Test code 1002393 AMODAB) will be added at an additional charge (CPT code(s): 83516). If Striated Muscle Ab  is greater than or equal to 1:40, then a titer (non-ordereable code 1015977)  will be added at an additional charge (CPT code(s): 86256) .

Instructions
Serum separator tube or plain red.

Transport Container
Centrifuge serum separator tube ASAP or within 1 hour of collection and transport, 1.5 mL serum (Min: 0.7 mL). If plain red, centrifuge ASAP or within 1 hour of collection and aliquot 1.5 mL serum into a standard transport tube. (Min: 0.7 mL) Repeated freeze-thaw cycles should be avoided.

Transport Temperature
Refrigerated.

Specimen Stability
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Plasma. Hemolyzed, lipemic, moderately icteric serum or contaminated specimens.

Methodology
Quantitative Radioimmunoassay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody/Semi-Quantitative Flow Cytometry

Setup Schedule
Monday - Friday

Report Available
1-8 days (From receipt at performing laboratory)

Limitations
This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Reference Range
Effective November 18, 2013
Acetylcholine Receptor Binding Antibody:
Negative: 0.0-0.4 nmol/L
Positive: 0.5 nmol/L or greater

Acetylcholine Receptor Blocking Antibody:
Negative: 0-26% blocking
Indeterminate: 27-41% blocking
Positive: 42% or greater blocking

Acetylcholine Receptor Modulating Antibody:
Negative: 0-45% modulating
Positive: 46% or greater modulating

Titin Antibody:
Negative: 0.00 to 0.45 IV
Indeterminate: 0.46 to 0.71 IV
Positive: 0.72 IV or greater

Striated Muscle Antibody IgG Screen: Less than 1:40 No antibody detected
Striated Muscle Antibody, IgG Titer: Less than 1:40 No antibody detected

Performing Laboratory
ARUP Laboratories



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.