Topiramate : 30965

Test Code

TOPIRQ or 30965

CPT Codes
80201

Instructions

Draw at peak (2-4 hours after dose) or trough (0.5-1 hour before dose) at steady state.

Plain red or green (no gel) (sodium heparin) tube.

Transport Container

Centrifuge plain red or green tube and aliquot 1 mL (Min: 0.5 mL) serum or plasma into a standard transport tube.

Transport Temperature

Refrigerated.

Specimen Stability

Ambient: 7 days; Refrigerated: 14 days; Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Do not use gel barrier/Serum Separator tubes.

Methodology
Chromatography/Mass Spectrometry

Setup Schedule

Tuesday - Saturday

Report Available

4 days (From receipt at performing laboratory)

Reference Range

Daily dose (mg)        Peak                           Trough
100                                6.5-9.2 mcg/mL          4.5-6.6 mcg/mL
200                              12.0-16.0 mcg/mL        8.0-12.0 mcg/mL
400                               20.0-30.0 mcg/mL      14.0-20.0 mcg/mL

Clinical Significance

Topiramate is an anticonvulsant used as an adjunctive treatment of partial-onset epilepsy. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.

Performing Laboratory
Quest Diagnostics

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.