Varicella-Zoster Virus (VZV) Viral Load by PCR, Blood : 1004389

Test Code
VZVQT or 1004389

Alias/See Also
Chickenpox by PCR; Herpes Zoster by PCR; Varicella-zoster Virus Detection by Real-Time PCR; VZV Dermal by PCR; VZV Detection by Real-Time PCR

CPT Codes
87799

Instructions
Peripheral Blood in a lavender top tube (EDTA).

Transport Container
Submit 5 mL Blood (Min. 1 mL) in lavender top tube. Do not centrifuge.

Transport Temperature
Refrigerated.

Specimen Stability
Ambient: 8 hours; Refrigerated: 5 days; Frozen: Unacceptable

Methodology
Qiagen ASR Quantitative Real-Time PCR

Setup Schedule
Monday & Wednesday & Friday

Report Available
1-4 days

Reference Range
Target Not Detected (TND)

Reportable Range: 100 to 1,000,000 copies/mL (log10 2.00 to log10 6.00 copies/mL)

Clinical Significance
Varicella-Zoster Virus (VZV) is a member of the Herpesviridae family that causes varicella (chickenpox) as primary infection and herpes zoster (shingles) upon reactivation. Chickenpox is a childhood infection presented as generalized vesicular rash on the dermis in normal children, usually before 10 years of age. After primary infection, the virus persists in latent form in the dorsal ganglion and may retrograde in elderly or immunocompromised host to cause shingles that presents as a unilateral vesicular eruption, generally in a dermatomal distribution. VZV infection in immunocompromised individuals often leads to a progressive disease state involving multiple organs. In allogeneic bone-marrow transplant recipients, VZV reactivation occurs in 20–50% of the cases within the first year after transplantation and prompt therapy with antiviral agents can reduce the risk of dissemination or postherpetic neuralgia. Of these, 15% may develop cutaneous dissemination and 5% may develop visceral dissemination. Detection of VZV DNA in plasma can facilitate the early recognition of complicated VZV-infection and therapeutic management of VZV-infections following transplant.

Performing Laboratory
med fusion



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.