A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Electrolytes, Feces
MessageTest Code
Alias/See Also
CPT Codes
82438, 84302, 84311
Includes
Potassium, Feces
Chloride, Feces
Preferred Specimen
Minimum Volume
Instructions
Note: Specimen must be shipped frozen to reduce the odor during shipping and to minimize the risk of the container rupturing due to gas accumulation.
This test only has clinical utility if performed on a watery fecal specimen.
Transport Container
Transport Temperature
Specimen Stability
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Coulometric Titration • Flame Photometric
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Reference Range
Clinical Significance
This panel measures sodium, potassium, and chloride in liquid stool. Measurements of electrolytes and osmotic gap in liquid stool help differentiate between secretory and osmotic diarrhea and, thus, guide further evaluation of chronic diarrhea [1,2].
Diarrhea can be categorized as secretory or osmotic depending on how the water content of stool is drawn in the intestine lumen. Secretory diarrhea is caused by defective electrolyte absorption that increases the stool's electrolyte levels. Conditions associated with secretory diarrhea include infection, neuroendocrine tumors, congenital chloridorrhea, intestinal resection, and diffuse mucosal disease [1]. Osmotic diarrhea is caused by the osmotic effect of a substance that retains water in the intestine lumen and leads to decreased electrolyte levels in the stool. Conditions associated with osmotic diarrhea include ingesting poorly absorbed solutes (eg, sorbitol, mannitol, and laxatives containing magnesium) and enzyme dysfunction (eg, lactose intolerance) [2].
Osmotic gap, calculated as the difference between the stool osmolality and twice the sum of the stool sodium and potassium levels, is useful in assessing the contribution of stool electrolytes to osmolality and differentiating between secretory and osmotic diarrhea [1,2].A theoretical fecal osmolality, approximately the same as plasma osmolality (290 mOsm/kg), is used in the calculation.
Measurement of chloride in liquid stool aids in the diagnosis of congenital or secondary chloridorrhea, which is characterized by increased excretion of chloride in stool. Low levels of chloride in liquid stool may also be seen in sodium sulfate-induced diarrhea [2].
The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.
References
1. Schiller LR. Pract Res Clin Gastroenterol. 2012;26(5):551-562.
2. Block DR, et al. Body fluids. In: Rifai R, et al. eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier Inc; 2022.
Performing Laboratory
Quest Diagnostics Nichols Institute-Chantilly VA |
14225 Newbrook Drive |
Chantilly, VA 20151-2228 |