Cholinesterase, Serum, Plasma, RBC

Test Code
CHST RBC&PLASMA(39481)

Quest Code
39481

CPT Codes
82480 (x2), 82482<br /> **This test is for non-California clients. For California patient testing, use test code 90369.**

Preferred Specimen
5 mL whole blood collected in an EDTA (lavender-top) tube and
1 mL plasma collected in an EDTA (lavender-top) tube and
1 mL serum

Minimum Volume
4 mL whole blood • 0.5 mL plasma • 0.5 mL serum

Instructions
5 mL refrigerated uncentrifuged whole blood (4 mL minimum) and 1 mL refrigerated plasma (0.5 mL minimum) drawn in lavender-top (EDTA) tubes AND, 1 mL refrigerated serum (0.5 mL minimum). Transfer plasma and serum to plastic transport tubes and send refrigerated with whole blood.

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 24 hours
Refrigerated: 7 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis; Lipemic

Methodology
Kinetic Spectrophotometric (KS)

Setup Schedule
Set up: Tues-Sat; Report available: 2-5 days

Limitations
Results may be depressed in patients who consume oral contraceptives. Hepatic disease may cause up to a 70% decrease in enzyme levels. Cholinesterase may be slightly elevated in patients with obesity or diabetes.

Reference Range
Cholinesterase, Serum  
  Male 3342-7586 IU/L
  Female 2673-6592 IU/L
Cholinesterase, RBC 9572-15031 IU/L
Cholinesterase, Plasma  
  Male 3334-7031 IU/L
  Female 2504-6297 IU/L


Clinical Significance
True Cholinesterase (RBC and plasma) activity is decreased in individuals with exposure to organophosphorous insecticides. True Cholinesterase, found in erythrocytes and nerve tissue, is responsible for inactivating acetylcholinesterase at nerve endings. With decreased enzyme activity, patients may display a range of nervous system dysfunction. Analysis of RBC and serum or plasma activity is useful in monitoring exposure and recovery.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Hwy
San Juan Capistrano, CA 92675-2042



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.