Cholinesterase, Plasma

Test Code
CHOLINESTERASE(335)

Quest Code
335

CPT Codes
82480<br /> **This test is for non-California clients. For California patient testing, use test code 90368.**

Preferred Specimen
1 mL plasma collected in an EDTA (lavender-top) tube

Minimum Volume
0.5 mL

Instructions

Draw an EDTA (lavender-top) tube of whole blood. Spin tube to separate plasma. Pour plasma into plastic aliquot tube and refrigerated until shipping. Ship plasma sample refrigerated. Do not send packed cells. Do not send one tube of whole blood.
Plasma cholinesterase results are not accurate if plasma sample is not separated from RBCs in a timely manner (within 1 hour). Hemolyzed plasma can lead to apparent increases in plasma cholinesterase activity, and could mask an enzyme deficiency.



Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 21 days
Refrigerated: 21 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis

Methodology
Kinetic Spectrophotometric (KS)

Setup Schedule
Tue, Thu, Sat

Report Available
1 to 4 Day(s)

Limitations
Results may be depressed in patients who consume oral contraceptives. Hepatic disease may cause up to a 70% decrease in enzyme levels. Cholinesterase may be slightly elevated in patients with obesity or diabetes.

Reference Range
Male 3334-7031 IU/L
Female 2504-6297 IU/L


Clinical Significance
Approximately 1 in every 2500 individuals has inherited defective or deficiency of the enzyme (pseudocholinesterase) that metabolizes succinylcholine (an anesthetic agent). With "normal" dosage, these individuals have prolonged apnea. Such individuals are responsive at much smaller concentrations of this anesthetic agent than the general population. Low concentrations of pseudocholinesterase are observed in individuals exposed to organophosphorous insecticides and patients with hepatic dysfunction.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Hwy
San Juan Capistrano, CA 92675-2042



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.