Collagen Cross-Linked N-Telopeptide (NTx), Urine

Test Code
N-T(36167)

Quest Code
36167

CPT Codes
82523, 82570

Includes
Creatinine

Preferred Specimen
2 mL unpreserved urine collected from second morning void submitted in a sterile leak-proof container

Minimum Volume
1 mL

Other Acceptable Specimens
Unpreserved random urine, or unpreserved catheterized urine, or unpreserved first void clean catch urine

Instructions
Do not use preservatives. Acidified specimen is not acceptable. Second morning void urine: Discard the first morning void. Collect the second morning void. Mix well.

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 72 hours
Refrigerated: 5 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Acidified specimen • Preserved specimen

Methodology
Chemiluminescence (CL)

Setup Schedule
Tue, Thu, Sat

Report Available
1 to 4 Day(s)

Reference Range
Collagen Cross-Linked N-Telopeptide (NTx), Random Urine
Male  
  18-29 Years 12-99 nM BCE/mM creat
  30-59 Years 9-60 nM BCE/mM creat
Female  
  Premenopausal 4-64 nM BCE/mM creat
Results are primarily used for monitoring the response to therapy. A value within the premenopausal reference range does not rule out osteoporosis nor the need for therapy.

Creatinine, Random Urine
≤6 Months 2-28 mg/dL
7-11 Months 2-31 mg/dL
1-2 Years 2-110 mg/dL
3-8 Years 2-130 mg/dL
9-12 Years 2-160 mg/dL
>12 Years Male 20-320 mg/dL
>12 Years Female 20-275 mg/dL


Clinical Significance
NTx is useful to assess bone resorption in patients with metabolic bone disease. The test is also useful in monitoring therapy to slow or halt osteoporotic bone loss. A decline of 30% or more of NTx over a six-month period suggests effective therapy.

Performing Laboratory
Quest Diagnostics Nichols Institute
27027 Tourney Road
Valencia, CA 91355-5386



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.