Clostridium difficile Cytotoxin Antibody Neutralization

Test Code
CDIFF-AB (34403)

Quest Code
34403

CPT Codes
87230

Preferred Specimen
2 mL serum

Minimum Volume
1 mL

Transport Container
Transport tube

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: Unacceptable
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Stool • Other sterile body fluids • Received beyond stability • Received in inappropriate container

Methodology
Antibody Neutralization

Setup Schedule
Tue

Report Available
2 to 8 Day(s)

Reference Range
<1:2 titer

Clinical Significance
Clostridium difficile is a major cause of antibiotic-associated diarrhea and pseudomembranous colitis. Clinical symptoms range from mild diarrhea to toxic megacolon. Antibodies may be present in a majority of adults and older children. Antibody production has been reported to be associated with carriers who appear asymptomatic and with reduced risk of recurrent disease. Natural exposure antibody may be a positive prognostic sign for patients with C. difficile disease.

Performing Laboratory
Quest Diagnostics Infectious Disease, Inc.
33608 Ortega Highway, Bldg B-West Wing
San Juan Capistrano, 92675-2042



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.