Carnitine

Test Code
CARN(70107)

Quest Code
70107

CPT Codes
82379

Includes
Carnitine, Total; Carnitine, Free; Carnitine, Esters; Esterified/Free Ratio

Preferred Specimen
1 mL serum

Patient Preparation
Patient should be in a well-fed state.

Minimum Volume
0.4 mL

Other Acceptable Specimens
Plasma collected in a sodium heparin (green-top) tube

Instructions
Separate serum by centrifugation. Avoid hemolysis. Remove serum and place in plastic tube. Freeze immediately after separation.

Transport Temperature
Frozen

Specimen Stability
Room temperature: 5 hours
Refrigerated: 5 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Moderate and gross hemolysis

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Mon, Wed, Fri-Sat

Report Available
3 to 4 Day(s)

Reference Range

See Laboratory Report



Clinical Significance
Serum carnitine analysis is useful in the diagnosis and monitoring of patients with carnitine deficiency (either primary or secondary). Primary carnitine deficiency is an autosomal recessively inherited genetic condition that affects carnitine uptake by cells and tissues through a defect in the plasma membrane carnitine transporter. Secondary carnitine deficiency can be seen in some disease states or in patients on carnitine-poor diets, but is also seen in a number of metabolic disorders. In these disorders, carnitine complexes with the accumulated substrate of the blocked metabolic step, and the resulting acylcarnitine ester is excreted in the urine, leading to a depletion of carnitine in the patient.

Performing Laboratory
Quest Diagnostics Nichols Institute San Juan Capistrano
33608 Ortega Hwy
San Juan Capistrano, CA 92675-2042



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.