Carbapenemase Detection, Phenotypic

Test Code

Quest Code

Alias/See Also

CPT Codes

Preferred Specimen
1 pure Enterobacteriaceae on slant, swab or plate

Organism identification must be supplied.

Transport Temperature
Room temperature

Specimen Stability
Room temperature: Varies with species and transport system
Refrigerated: Varies with species and transport system
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Mixed isolates • Organisms other than Enterobacteriaceae • Nonviable organisms

Modified Disk Diffusion

Setup Schedule

Report Available
2 to 3 Day(s)

Reference Range
See Laboratory Report

Clinical Significance
Klebsiella pneumoniae carbapenemase (KPC)-producing organisms can be a difficult therapeutic challenge, due to their broad spectrum of resistance to beta-lactams. The profile of KPC beta-lactam resistance is similar to that of extended-spectrum beta-lactamases (ESBLs) with the addition of resistance to the carbapenems (imipenem, meropenem, doripenem, and ertapenem). In addition, KPC producers may be cross-resistant to a wide range of antibiotic classes including the aminoglycosides, fluoroquinolones, and sulfa drugs.

Performing Laboratory
Quest Diagnostics Infectious Disease, Inc.
33608 Ortega Highway, Bldg B-West Wing
San Juan Capistrano, 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.