17 Hydroxypregnenolone

Test Code
17HYDRO(8352)

Quest Code
8352

CPT Codes
84143

Preferred Specimen
2 mL serum collected in red-top tube (no gel)

Minimum Volume
0.4 mL

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 24 hours
Refrigerated: 5 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature • Serum separator tube (SST) • Gross hemolysis • Grossly lipemic • Grossly icteric

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Sun-Fri

Report Available
2 to 5 Day(s)

Limitations
Infants with 21-hydroxylase deficiency may present with non-elevated results.

Reference Range
Adult Males ≤700 ng/dL

Adult Females, Pre-Menopausal
Mid Follicular 38-378 ng/dL
Surge 33-583 ng/dL
Mid Luteal 70-470 ng/dL

Pediatric Male and Female
<30 days ≤3013 ng/dL
1-11 months ≤869 ng/dL
1 year ≤557 ng/dL
2 years ≤487 ng/dL
3 years ≤541 ng/dL
4 years ≤561 ng/dL
5 years ≤564 ng/dL
6 years ≤561 ng/dL
7 years ≤549 ng/dL
8 years ≤569 ng/dL
9 years ≤590 ng/dL
10 years ≤594 ng/dL
11 years ≤629 ng/dL
12 years ≤666 ng/dL
13 years ≤678 ng/dL
14 years ≤706 ng/dL
15 years ≤735 ng/dL
16 years ≤739 ng/dL
17 years ≤756 ng/dL


Clinical Significance
17-Hydroxypregnenolone is useful in the diagnosis of 3-Beta-Hydroxylase enzyme deficiency, a rare cause of congenital adrenal hyperplasia, and 17-Hydroxylase (P450c17) enzyme deficiency.

Performing Laboratory
Quest Diagnostics Nichols Institute San Juan Capistrano
33608 Ortega Hwy
San Juan Capistrano, CA 92675-2042



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.