Omega-3 and -6 Fatty Acids

Test Code
OMEGA (91009)

Quest Code

CPT Codes

Preferred Specimen
2 mL plasma collected in an EDTA (lavender-top) tube

Patient Preparation
Overnight fasting is required

Minimum Volume
0.6 mL

Other Acceptable Specimens
Plasma collected in: PPT potassium EDTA (white-top) tube • Serum collected in a red-top tube (no gel)

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 35 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly icteric • Lipemic • Plasma not collected in EDTA tubes • Serum separator tubes

Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Mon-Sat; Report available: 2-3 days

Reference Range
Omega-3 (EPA+DHA) Index 1.4-4.9 %
  Optimal >3.2 %
  Moderate 2.2-3.2 %
  High <2.2 %
Omega-6/Omega-3 Ratio 5.7-21.3
EPA/Arachidonic Acid Ratio ≤0.2
Arachidonic Acid 5.2-12.9 %
EPA 0.2-1.5 %
DHA 1.2-3.9 %

Clinical Significance
1. Baseline and monitoring of individuals with known CVD (acute and chronic) to deterimine Rx and compliance.
2. Identify patients with known CVD risk with low omega-3 levels who may be candidates for supplementation/therapy.
3. Monitor patients on omega-3 supplementation/therapy to determine efficacy of treatment.
4. Potential role in risk reduction for non-CVD outcomes-aged related macular degeneration, RA, cancer, etc. (early data).

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.