CATECHOLAMINES, FRACTIONATED, 24-HOUR URINE WITH CREATININE

Test Code
CATFU 24HR Urine (39627)

Quest Code
39627

CPT Codes
82384 82570

Includes
Creatinine, Norepinephrine, Epinephrine, Dopamine, and Total Catecholamines (calculated)

CPT code 81050 may be added at an additional charge for volume measurement

Preferred Specimen
Urine with HCL 24 hour 10 mL

INSTRUCTIONS:
Patient Preparation: It is preferable for the patient to
be off medications for three days prior to collection.
However, common antihypertensives (diuretics, ACE
inhibitors, calcium channel blockers, alpha and beta
blockers) cause minimal or no interference. Patient should
avoid alcohol, coffee, tea, tobacco and strenuous exercise
prior to collection. Instructions: Collect 24-hour urine
with 25 mL 6N HCl to maintain a pH < or = 3. If no
preservative is used, specimen must be stored refrigerated
during collection but shipped frozen and pH must be < or =
6. Record 24-hour urine volume and patient's age on test
request form and on urine container.

NOTE:
Preferred:
10 mL (5 mL minimum) aliquot from a 24-hour urine that has
been preserved with 25 mL 6N HCl, collected in a plastic,
24-hour urine container.
Acceptable:
Aliquot from a 24-hour urine, unpreserved, with a pH < or =
6, collected in a plastic, 24-hour urine container.
Transport Temperature:
Preserved Urine: Room temperature
Unpreserved Urine: Frozen
Specimen Stability:
Unpreserved Urine: Room temperature and Refrigerated -
Unacceptable; Frozen - 30 days
Reject Criteria:
Preserved urine received refrigerated with pH > 3;
Unpreserved urine received frozen with pH > 6.
Methodology: High Performance Liquid Chromatography
Assay: LDT with
message

Minimum Volume
5 mL Urine with HCL 24 hour

Other Acceptable Specimens
#1) (Urine 24 hour) (Sterile) (10 mL) (Frozen - 30 Day(s))

Transport Container
Sterile

Specimen Stability
Frozen - 49 Day(s)
Refrigerated - 30 Day(s)
Room Temperature - 7 Day(s)

Methodology
High Performance Liquid Chromatography (HPLC)

Setup Schedule
Mon-Fri

Report Available
3 to 5 Day(s)

Limitations
Recent surgery, traumatic injury, upright posture, cold, anxiety, pain, clonidine withdrawal, and concurrent acute or chronic illness may produce elevated results..

Reference Range
See Laboratory Report

Clinical Significance
The three catecholamines (norepinephrine, epinephrine and dopamine) are the principal secretory products of neural tissue. Clinically, the measurement of circulating catecholamines is valuable in the diagnosis of catecholamine secreting tumors associated chiefly with hypertension (pheochromocytomas, neuroblastomas and gangliomas) and with the evaluation of orthostatic hypotension.

Performing Laboratory
QUEST DIAGNOSTICS-NICHOLS INST 33608 ORTEGA HIGHWAY SAN JUAN CAPISTRANO, CA 92675



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.