Catecholamines, Fractionated, Random Urine

Test Code
CAT AR (5244)

Quest Code
5244

CPT Codes
82384, 82570

Includes
Creatinine, Norepinephrine, Epinephrine, Dopamine, and Total Catecholamines (calculated)

Preferred Specimen
10 mL urine with 6N HCl

Patient Preparation
It is preferable for the patient to be off medications for a minimum of 18-24 hours prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise for 8-12 hours prior to collection.

Minimum Volume
5 mL

Instructions
After urine collection, add 6N HCl to maintain a pH below 3. Urine without preservative is acceptable if pH is below 6 and the sample is shipped frozen.

Transport Container
Sterile

Transport Temperature
Preserved urine: Room temperature
Unpreserved urine: Frozen

Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days

Methodology
High Performance Liquid Chromatography (HPLC)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Mon-Fri

Report Available
3 to 6 Day(s)

Limitations
Recent surgery, traumatic injury, upright posture, cold, anxiety, pain, clonidine withdrawal, and concurrent acute or chronic illness may produce elevated results.

Reference Range

See Laboratory Report



Clinical Significance
The three catecholamines (Norepinephrine, epinephrine, and dopamine) are the principal secretory products of neural tissue. Clinically, the measurement of circulating catecholamines is valuable in the diagnosis of catecholamine secreting tumors associated chiefly with hypertension (pheochromocytomas, neuroblastomas, and gangliomas) and with the evaluation of orthostatic hypotension.

Performing Laboratory
Quest Diagnostics Nichols Institute San Juan Capistrano
33608 Ortega Hwy
San Juan Capistrano, CA 92675-2042



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.