Osteocalcin, N-MID

Message
PLAIN RED : NO GEL
FREEZE SERUM AS SOON AS POSSIBLE.

Test Code
OSTEO (16322)

Quest Code
16322

CPT Codes
83937

Preferred Specimen

1 mL serum



Patient Preparation
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

Minimum Volume
0.5 mL

Instructions
Collect blood in a red-top tube (no gel). Allow blood to clot at room temperature (20-26° C) and centrifuge immediately to separate the serum from the cells. Freeze as soon as possible.

Transport Temperature
Frozen

Specimen Stability
Room temperature: Unacceptable
Refrigerated: 24 hours
Frozen 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Heat inactivated specimens • Specimens stabilized with azide • Patient administered with biotin within 8 hours

Methodology
Electrochemiluminescence (ECLIA)

Setup Schedule
Set up: Tue, Thur, Sat; Report available: 1-4 days

Reference Range
  Male (ng/mL) Female (ng/mL)
0-4 Years Not established Not established
5-9 Years 47-142 47-142
10-13 Years 49-167 49-167
14-17 Years 26-203 14-85
>17 Years 9-38 8-32


Clinical Significance
Osteocalcin, the most abundant non-collagen protein in bone matrix, is a bone-specific, calcium binding protein. Serum osteocalcin levels are related to the rate of bone turnover in various disorders of bone metabolism, e.g., osteoporosis, primary and secondary hyperparathyroidism, and Paget's disease.

Performing Laboratory
Quest Diagnostics Nichols Institute
27027 Tourney Road
Valencia, CA 91355-5386



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.