CARBO-DEFICIENT TRANSFERRIN

Message
SENT TO QUEST TO SEND TO MAYO

Test Code
CDT (A52289)

Alias/See Also
CDT (Carbohydrate Deficient Transferrin)
Transferrin for Carbohydrate Deficient Transferrin (CDT)
Transferrin Isoforms

CPT Codes
82373

Preferred Specimen
SERUM

Minimum Volume
0.1 mL

Other Acceptable Specimens
PLAIN RED (PREFERRED)
LG-RED
GOLD SST

Instructions
. Patient's age is required. Reason for referral is required if patient is <21 years old.

2. This test is for evaluation of alcohol abuse.


Specimen Stability
FROZEN: 2 MONTHS
REF: 4 DAYS

Clinical Significance
Chronic alcoholism causes a transient change in the glycosylation pattern of transferrin where the relative amounts of disialo- and asialotransferrin (carbohydrate deficient transferrin: CDT) are increased over the amount of normally glycosylated tetrasialotransferrin. This recognition led to the use of CDT in serum as marker for chronic alcohol abuse.

CDT typically normalizes within several weeks of abstinence of alcohol use. However, it is important to recognize that there are other causes of abnormal CDT levels, which include congenital disorders of glycosylation and other genetic and non-genetic causes of acute or chronic liver disease.

 

CDT testing alone is not recommended for general screening for alcoholism; however, when combined with other methods (ie, gamma-glutamyltransferase, mean corpuscular volume, patient self-reporting, ethylglucuronide analysis) clinicians can expect to identify the majority of patients who consume a large amount of alcohol.

Performing Laboratory
MAYO MEDICAL LABORATORIES 3050 SUPERIOR DRIVE NW ROCHESTER, MINNESOTA 55901



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.