Test Code
COPB (4870)

Quest Code

CPT Codes

Preferred Specimen
2 mL plasma collected in an EDTA or sodium heparin (royal blue-top) tube

Minimum Volume
0.7 mL

Other Acceptable Specimens
Serum collected in a no additive (royal blue-top) tube

Separate serum or plasma from cells within two hours. Transfer separated serum or plasma to a plastic acid-washed or metal-free vial.

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 5 days
Refrigerated: 10 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Serum or plasma not separated from cells • Samples submitted in non-trace metal or non-acid washed containers

Inductively-Coupled Plasma/Mass Spectrometry (ICP/MS) or Atomic Spectroscopy (AS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the US Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Sun, Wed, Fri

Report Available
1 to 4 Day(s)

Reference Range
≤5 Months   38-104 mcg/dL
6-11 Months   24-152 mcg/dL
12 Months-23 Months 76-193 mcg/dL
1-3 Years 87-187 mcg/dL
4-5 Years 56-191 mcg/dL
6-9 Years 117-181 mcg/dL
10-13 Years 87-182 mcg/dL
14-17 Years 75-187 mcg/dL
≥18 Years 70-175 mcg/dL 

Clinical Significance
Copper is an essential element that is a cofactor of many enzymes. Copper metabolism is disturbed in Wilson's disease, Menkes disease, primary biliary cirrhosis, and Indian childhood cirrhosis. Copper concentrations increase in acute phase reactions and during the third trimester of pregnancy. Copper concentrations are decreased with nephrosis, malabsorption, and malnutrition. Copper concentrations are also useful to monitor patients, especially preterm newborns, on nutritional supplementation. Results of copper are often interpreted together with ceruloplasmin.

Performing Laboratory
Quest Diagnostics Nichols Institute
27027 Tourney Road
Valencia, CA 91355-5386

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.