Cyclic Citrullinated Peptide (CCP) Antibody (IgG)

Test Code
CYCP (11173)

Quest Code
11173

CPT Codes
86200

Preferred Specimen
1 mL serum

Minimum Volume
0.5 mL

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Gross lipemia • Plasma

Methodology
Immunoassay (IA)

Setup Schedule
Sun, Tue-Sat

Report Available
1 to 3 Day(s)

Limitations
The presence of immune complexes may cause false-positive results due to increased non-specific binding.

Reference Range
Negative <20 Units
Weak positive 20-39 Units
Moderate positive 40-59 Units
Strong positive >59 Units


Clinical Significance
A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from patients with other diseases such as hepatitis C infection. Rheumatoid Arthritis Classification Criteria include CCP IgG Antibody, rheumatoid factor, C-reactive protein and erythrocyte sedimentation rate (ESR). Approximately 70% of patients with Rheumatoid Arthritis are positive for Anti-CCP IgG, while only about 2% of random blood donors and disease controls subjects are positive.

Performing Laboratory
Quest Diagnostics Nichols Institute
27027 Tourney Road
Valencia, CA 91355-5386



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.