Cardiolipin Antibodies (IgA, IgG, IgM)

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Aliases:
Anti-Phospholipid Antibodies

Anticardiolipin Antibodies

Antiphospholipid Antibodies

Cardiolip

Cardiolipin Antibodies, IgG, IgA, and IgM

Phospholip

Phospholipid Antibodies (Cardiolipin Antibodies), IgG IgA, and IgM
 

Test Code
ACA (7352)

Quest Code
7352

CPT Codes
86147 (x3)

Preferred Specimen
1 mL citrated plasma collected in a 3.2% sodium citrate (light blue-top) tube

Minimum Volume
0.5 mL

Other Acceptable Specimens
Serum

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic

Methodology
Immunoassay (IA)

Setup Schedule
Mon-Sat

Report Available
3 to 5 Day(s)

Reference Range

Cardiolipin Antibody (IgA)
≤11 APL Negative
12-20 APL Indeterminate
21-80 APL Low to medium positive
>80 APL High positive

Cardiolipin Antibody (IgG)
≤14 GPL Negative
15-20 GPL Indeterminate
21-80 GPL Low to medium positive
>80 GPL High positive

Cardiolipin Antibody (IgM)
≤12 MPL Negative
13-20 MPL Indeterminate
21-80 MPL Low to medium positive
>80 MPL High positive


Clinical Significance
Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly systemic lupus erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. Elevations of CA associated with increased risk have also been seen in idiopathic thrombocytopenic purpura, rheumatoid and psoriatic arthritis, and primary Sjögren's syndrome.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.