Oxycodone and Metabolite, Quantitative, Serum

Test Code
OXY (4176)

Quest Code
4176

CPT Codes
80365 (HCPCS: G0480)

Includes
Oxycodone and Oxymorphone

Preferred Specimen
5 mL serum collected in a red-top tube (no gel)

Minimum Volume
3 mL

Instructions

Do not use serum separator tubes.
Note: This test is for clinical purposes only.



Transport Temperature
Room temperature

Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 7 days

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Mon, Wed, Fri

Report Available
2 to 4 Day(s)

Reference Range
Oxycodone 10-100 ng/mL
Oxymorphone
Peak plasma concentrations 1 hour after a single immediate-release tablet containing 5 mg of Oxycodone: 9-38 ng/mL.
Peak plasma concentrations within 2.5 hours after 10 mg of immediate-release preparation of Oxycodone: 13-46 ng/mL.
Mean peak plasma concentrations following a single dose of a 40 to 80 mg controlled-release Oxycodone preparation: 39-100 ng/mL.
Toxicity may be significant at greater than 200 ng/mL.
However, concentrations associated with toxicity are variable and depend on an individual's tolerance to the drug.

Clinical Significance
For therapeutic drug monitoring of oxycodone (Oxycontin®, Percocet®, Percodan®). Oxycodone is a semisynthetic opioid analgesic. Steady state concentration is reached in 24-36 hours after initiation of therapy. Elimination half-life of oxycodone is 4.5 hours for controlled release and 3.2 hours for immediate release formulations. Peak plasma concentration of oxycodone is 11, 21, 39, 99, or 156 ng/mL after a single oral dose of 10, 20, 40, 80, or 160 mg respectively. Oxymorphone is a minor but active metabolite of oxycodone that is present at lower concentration in the circulation. Therapeutic concentrations for oxymorphone have not been established.

Performing Laboratory
Quest Diagnostics Nichols Institute
27027 Tourney Road
Valencia, CA 91355-5386



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.