Cocaine and Metabolites Confirmation Serum

Test Code
COCAINE (4170)

Quest Code
4170

CPT Codes
80353

Preferred Specimen
5 mL serum

Minimum Volume
2.5 mL

Instructions
Do not use serum separator tubes

Please note: This test is for clinical purposes only. Reference ranges indicate reporting limits.

Specimen Stability
Refrigerated: 72 hours
Frozen: 7 days

Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Tues, Sat; Report available: 1-4 days

Reference Range
See Laboratory Report

Clinical Significance
Cocaine is metabolized mainly to benzoylecgonine and ecgonine methylester. Cocaethylene is an indication of concurrent cocaine and alcohol consumption. Serum half-life of cocaine is 1-5 hours. Benzoylecgonine appears in circulation 15-30 minutes after cocaine administration. Elimination half-life of benzoylecgonine is 5-6 hours. Benzoylecgonine will be detectable in urine after 2-3 hours and urine remains positive for 2-3 days (longer for chronic abusers) after cocaine use.

Performing Laboratory
Quest Diagnostics Nichols Institute
27027 Tourney Road
Valencia, CA 91355-5386



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.