Cryptococcal Antigen, Latex Screen with Reflex to Titer

Test Code

Quest Code

CPT Codes

If Cryptococcal Antigen Screen is positive, a Titer will be performed at an additional charge (CPT code(s): 86406).

Preferred Specimen
1 mL CSF or 2 mL serum

Minimum Volume
0.5 mL

Centrifuge serum specimens within 1 hour of collection. Transfer serum to clean, plastic, screw-capped vial(s). Refrigerate samples and transport on cold packs or freeze samples and transport on dry ice.

Transport Temperature
Refrigerated (cold packs)

Specimen Stability

Refrigerated: 7 days
Frozen: 60 days

Latex Agglutination (LA)

Setup Schedule
Set up: Mon-Fri; Report available: 1-4 days

Patients with capnocytophaga canimorsus and tichosporon beigelli infections may test falsely-positive.

Reference Range
Not detected

Clinical Significance
The encapsulated soil yeast Cryptococcus neoformans causes Cryptococcosis. Pulmonary infection is acquired by inhalation of the organism and is usually subclinical in the immunocompetent host. Dissemination may occur in an immunocompromised patient, often to the meninges.

Performing Laboratory
Quest Diagnostics Nichols Institute
27027 Tourney Road
Valencia, CA 91355-5386

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.