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AFP, Maternal Serum
MessagePerforming Lab: Central Lab
Test Code
3363
Alias/See Also
Sunquest: AFP
CPT Codes
82105
Preferred Specimen
0.3 mL Serum Separator (gold-top) tube
Minimum Volume
0.2 mL
Other Acceptable Specimens
Red, Red/Gray
Instructions
Ordering:
This test provides a risk for Open Neural Tube Defects (ONTD) only. If risks for Down Syndrome and Trisomy 18 are desired, please order Epic code 3777 (Prenatal Quad Screen).
Collection:
Sample must be collected between 15-20 completed weeks gestation. The Opitmal time to collect the sample is between 16-18 weeks gestation.
Samples should be collected prior to the initiation of amniocentesis as increased levels of AFP may occur following amniocentesis.
Processing:
Must be frozen at -20 degrees C if not tested within 48 hours of collection.
This test provides a risk for Open Neural Tube Defects (ONTD) only. If risks for Down Syndrome and Trisomy 18 are desired, please order Epic code 3777 (Prenatal Quad Screen).
Collection:
Sample must be collected between 15-20 completed weeks gestation. The Opitmal time to collect the sample is between 16-18 weeks gestation.
Samples should be collected prior to the initiation of amniocentesis as increased levels of AFP may occur following amniocentesis.
Processing:
Must be frozen at -20 degrees C if not tested within 48 hours of collection.
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 48 hours
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Plasma is not an acceptable specimen type
Gross Hemolysis
Specimen not frozen within 48 hours of collection
Gross Hemolysis
Specimen not frozen within 48 hours of collection
Methodology
Chemiluminescence
Setup Schedule
Tuesday, Wednesday, Friday
Report Available
Same day
Reference Range
No elevated risk for Open Neural Tube Defects
Clinical Significance
Measurement of AFP in maternal serum can be used to help identify pregnancies at increased risk for open neural tube defects.
