Anti dsDNA Antibody by EIA

Message

Performing Lab: Central Lab

Test Code

2406

Alias/See Also

Sunquest: DSDNA; Anti-dsDNA; native DNA, DNA Double Stranded Antibody

CPT Codes
86225

Preferred Specimen

2.0 mL Serum Separator (gold-top) tube

Minimum Volume

0.5 mL

Transport Temperature

Refrigerated

Specimen Stability

Refrigerated: 7 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross Hemolysis or Lipemia

Methodology
Quantitative Enzyme Immunoassay (EIA)

Setup Schedule

Monday & Thursday

Report Available

5 business days

Reference Range

<25 IU: Negative
25-30: Borderline Positive
30-60: Low Positive
60-200: Positive
>200: Strong Positive

Clinical Significance

Antibodies to double-stranded DNA (native DNA, nDNA, dsDNA) are an accepted criterion by the American College of Rheumatology for the diagnosis of idiopathic systemic lupus erytematosus (SLE or LE). dsDNA antibodies are detectable in approximately 85% of patients with untreated SLE, and are rarely detectable in other connective tissue diseases. The levels of dsDNA are known to fluctuate with disease activity in SLE and often increase prior to an increase in inflammation.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.