Anti-CCP Antibody

Message

Performing Lab: Central Lab

Test Code

4287

Alias/See Also

Sunquest: RCCP; Cyclic Citrulline Peptide Antibody; Anti-cyclic citrullinated peptide

CPT Codes
86200

Preferred Specimen

2.0 mL Serum Separator (gold-top) tube

Minimum Volume

0.5 mL

Other Acceptable Specimens

Red, Red/Gray

Instructions

Freeze within 48 hours of collection

Transport Temperature

Refrigerated

Specimen Stability

Refrigerated: 2 days
Frozen: 4 weeks

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Plasma is not an acceptable specimen type.; Grossly hemolyzed or lipemic samples

Methodology
Fluoroenzymeimmunoassay

Setup Schedule

Monday, Wednesday, Friday

Report Available

Same Day

Reference Range

0 - 6 U/mL: Negative
7 - 10 U/mL: Equivocal
>=11 U/mL: Positive

Clinical Significance

Rheumatoid Arthritis (RA) is one of the most common systemic autoimmune diseases characterized by chronic inflammation of the joints and may lead to progressive erosions and cartilage destruction. Antibodies highly specific for RA are described as citrullinated or citrulline peptides. Anti-CCP IgG testing has been found to be better at distinguishing RA than either the perinuclear autoantibody test or the test for Rheumatoid Factor. Not all individuals with RA will have detectable anti-CCP antibodies. The antigen preparation used for this assay is described as CCP2 or second generation. Assays using CCP2 show a sensitivity of approximately 70% and specificity of 96%.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.