Anti-SSB Antibody

Message

Performing Lab: Central Lab

Test Code

4767

Alias/See Also

Sunquest: LASSB; Anti-La Antibody, Sjögren's Antibody

CPT Codes
86235

Preferred Specimen

0.5 mL Serum Separator (gold-top) tube

Minimum Volume

0.2 mL

Other Acceptable Specimens

Red, Red/Gray

Transport Temperature

Refrigerated

Specimen Stability

Refrigerated: 7 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Plasma is not an acceptable specimen type. Hemolyzed or grossly lipemic samples

Methodology
Fluoroenzymeimmunoassay

Setup Schedule

Monday, Wednesday, Friday

Report Available

Same day

Reference Range

0 - 6 U/mL: Negative
7 - 10 U/mL: Equivocal
>=11 U/mL: Positive

Clinical Significance

SS-B/La antibodies are the serological hallmark of Sjögren's syndrome but a small proportion of patients remain anti-SS-B/La negative. Reported in 6-15 % of sera from SLE patients, SS-B/La antibodies are associated with a lower prevalence of dsDNA antibodies and renal disease in these patients. Although a strong association of neonatal lupus erythematosus (NLE) with anti-SS-A/Ro was recognized first, the majority of mothers with babies with NLE are now known to have serum SS-B/La antibodies as well.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.