IgM (Immunoglobulin M)

Message

Performing Lab: Central Lab

Test Code

0519

Alias/See Also

Sunquest: IGM

CPT Codes
82784

Preferred Specimen

0.6 mL Lithium Heparin Plasma (light green-top) tube

Minimum Volume

0.3 mL

Other Acceptable Specimens

Serum separator (gold-top), Red, Red/Gray

Transport Temperature

Refrigerated

Specimen Stability

Refrigerated: 7 days

Methodology
Immunoturbidimetric

Setup Schedule

Monday - Friday

Report Available

Same day

Reference Range

Sex	Age	Reference Range
Male and Female	0-3 Months	6-21 mg/dL
Male	3 Months - 1 Year	17-143 mg/dL
Male	>1 Year - 12 Years	41-183 mg/dL
Male	>12 Years	22-240 mg/dL
Female	3 Months- 1 Year	17 - 150 mg/dL
Female	>1 Year - 12 Years	47 - 240 mg/dL
Female	> 12 Years	33 - 293 mg/dL

Clinical Significance

IgM is the first immunoglobulin synthesized in response to antigenic challenge and accounts for 5 to 10% of the total circulating immunoglobulins. The role of IgM in activating the complement cascade and promoting phagocytosis makes it an important factor in eliminating particulate antigens and microorganisms from the circulation. IgM levels are used to evaluate monoclonal proteins seen on serum electrophoresis, and to monitor the progression or therapeutic response of patients with macroglobulinemia. Levels are frequently increased in viral infections, rheumatoid arthritis, and chronic hepatocellular disease, active sarcoidosis, Waldenström’s macroglobulinemia, and malignant lymphoma. Decreased levels are seen in association with recurrent, chronic, or severe infections, multiple myeloma (IgA or IgG), and protein-losing enteropathy (but not nephritic syndrome).

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.