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IgE (Immunoglobulin E)
MessagePerforming Lab: Central Lab
Test Code
0517
Alias/See Also
Sunquest: IGE
CPT Codes
82785
Preferred Specimen
0.3 mL Serum Separator (gold-top) tube
Minimum Volume
0.2 mL
Other Acceptable Specimens
Red, Red/Gray
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 7 days
Methodology
Fluorescence Enzyme Immunoassay (FEIA)
Setup Schedule
Monday - Friday
Report Available
Same day
Reference Range
0 – 6 Weeks: <8.8 kU/L
7 Weeks – 3 Months: <17.0 kU/L
4 – 6 Months: <30.0 kU/L
7 – 9 Months: <39.0 kU/L
10 – 23 Months: <53.0 kU/L
2 Years: <93.0 kU/L
3 Years: <128.0 kU/L
4 Years: <160.0 kU/L
5 Years: <192.0 kU/L
6 Years: <224.0 kU/L
7 Years: <248.0 kU/L
8 Years: <280.0 kU/L
9 Years: <304.0 kU/L
10 Years: <328.0 kU/L
> 10 Years: <127.0 kU/L
7 Weeks – 3 Months: <17.0 kU/L
4 – 6 Months: <30.0 kU/L
7 – 9 Months: <39.0 kU/L
10 – 23 Months: <53.0 kU/L
2 Years: <93.0 kU/L
3 Years: <128.0 kU/L
4 Years: <160.0 kU/L
5 Years: <192.0 kU/L
6 Years: <224.0 kU/L
7 Years: <248.0 kU/L
8 Years: <280.0 kU/L
9 Years: <304.0 kU/L
10 Years: <328.0 kU/L
> 10 Years: <127.0 kU/L
Clinical Significance
IgE is a mediator of the allergic response. Quantitative measurement of serum IgE, when integrated with other clinical indicators, can provide useful information for the differential clinical diagnosis of atopic and non-atopic disease. Patients with atopic disease, including allergic asthma, allergic rhinitis, and atopic dermatitis commonly have moderately elevated serum IgE levels. However, a serum IgE level which is within the range of normally expected values does not rule out a limited set of IgE-dependent allergies.
Total serum IgE measurements may be most valuable for children to assist in differentiating between atopic and non-atopic individuals and to predict the probability of developing allergic disorders. Elevated serum IgE in neonates and children under two years of age is often associated with the development of a clinically significant atopic allergic disorder. There is not, however, a close correlation between the severity of the allergic reaction and the concentration of IgE antibodies in serum.
Total serum IgE levels may also be elevated in the presence of some clinical conditions that are not related to allergy. These clinical conditions include parasitic infections, immunodeficiency states, autoimmune diseases, Hodgkin’s disease, bronchopulmonary aspergillosis, IgE myeloma, and Sezary syndrome.
Total serum IgE measurements may be most valuable for children to assist in differentiating between atopic and non-atopic individuals and to predict the probability of developing allergic disorders. Elevated serum IgE in neonates and children under two years of age is often associated with the development of a clinically significant atopic allergic disorder. There is not, however, a close correlation between the severity of the allergic reaction and the concentration of IgE antibodies in serum.
Total serum IgE levels may also be elevated in the presence of some clinical conditions that are not related to allergy. These clinical conditions include parasitic infections, immunodeficiency states, autoimmune diseases, Hodgkin’s disease, bronchopulmonary aspergillosis, IgE myeloma, and Sezary syndrome.
