Estradiol

Message

Performing Lab: Central Lab

Test Code

0477

Alias/See Also

Sunquest: ESTRA

CPT Codes
82670

Preferred Specimen

200 uL Lithium Heparin Plasma (light green-top) tube

Minimum Volume

200 uL

Other Acceptable Specimens

Serum separator (gold-top), (red-top)

Transport Temperature

Refrigerated

Specimen Stability

Refrigerated: 5 days
Frozen: 5 days

Methodology
Chemiluminesent Microparticle Immunoassay (CMIA)

Setup Schedule

Monday - Friday

Report Available

Same day.

Reference Range

Normal Menstruating Females:
Follicular Phase: 21 - 251 pg/mL
Mid Cycle Phase: 38 - 649 pg/mL
Luteal Phase: 21 - 312 pg/dL
Post Menopausal not on HRT: < 10 - 25 pg/dL
Post Menopausal on HRT: < 10 - 144 pg/dL

Male:11 - 44 pg/mL

Clinical Significance

Estradiol is produced by the adrenals, placenta, and testes and is the principal estrogen secreted by the ovaries. Over 98% of circulating estradiol is bound to serum proteins, principally sex hormone-binding globulin (SHBG). Metabolic clearance of estradiol is effected by conversion to estrone, and by hydroxylation and conjugation with sulfate or glucuronide. Estradiol normally exerts negative feedback control on gonadotropin release; however, as estradiol production accelerates with the rapid growth of the dominant follicle, this feedback becomes positive, causing a surge in LH secretion and ovulation to occur. The measurement of estradiol is useful in assessing a variety of menstrual dysfunctions including delayed puberty, amenorrhoea and menopause.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.