C3 Complement

Message

Performing Lab: Central Lab

Test Code

0453

Alias/See Also

Sunquest: C3

CPT Codes
86160

Preferred Specimen

3 uL Lithium Heparin Plasma (light green-top) tube

Minimum Volume

3 uL (does not include dead volume)

Other Acceptable Specimens

Serum separator (gold-top), Red, Red/Gray

Transport Temperature

Refrigerated

Specimen Stability

Refrigerated: < 8 days
Frozen: < 8 days

Methodology
Immunoturbidimetric

Setup Schedule

Monday - Friday

Report Available

Same day.

Reference Range

Female: 83 - 193 mg/dL
Male: 82 - 185 mg/dL

Clinical Significance

C3 is the most abundant protein of the complement system. As one of the major mediators of inflammation, it serves as the functional link between the classical and alternative pathway of complement system activation. The activation of complement produces a number of biological effects such as the destruction of foreign agents (bacteria, yeast, viruses), release of histamine, and the release of leukocytes from the bone marrow. C3 levels may be used as an aid in the diagnosis of inherited or collagen vascular diseases such as active lupus nephritis, severe infections, and inflammation. Increased levels may be found after trauma or surgery, biliary obstruction, or focal glomerulosclerosis.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.