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FSH (Follicle Stimulating Hormone)
MessagePerforming Lab: Central Lab
Test Code
0196
Alias/See Also
Sunquest: FSH
CPT Codes
83001
Preferred Specimen
- Lithium Heparin Plasma (light green-top)
Minimum Volume
75 uL
Other Acceptable Specimens
Gold Serum Separator Tube
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: < 7 days
Frozen: < 12 months
Frozen: < 12 months
Methodology
Chemiluminescent Microparticle Immunoassay (CMIA)
Setup Schedule
Monday - Friday
Report Available
Same day.
Reference Range
Normal Menustrating Females:
Follicular Phase: 3.0 - 8.1 mIU/mL
Midcycle Peak: 2.6 - 16.7 mIU/mL
Luteal Phase: 1.4 - 5.5 mIU/mL
Postmenopausal Females without HRT: 26.8 - 133.0 mIU/mL
Normal Males: 1.0 - 12.0 mIU/mL
Follicular Phase: 3.0 - 8.1 mIU/mL
Midcycle Peak: 2.6 - 16.7 mIU/mL
Luteal Phase: 1.4 - 5.5 mIU/mL
Postmenopausal Females without HRT: 26.8 - 133.0 mIU/mL
Normal Males: 1.0 - 12.0 mIU/mL
Clinical Significance
FSH is secreted by the anterior pituitary under the control of hypothalamic gonadotrophin releasing hormone. The function of FSH in both males and females is to facilitate the development and maintenance of the gonadal tissues. These tissues synthesize and secrete steroid hormones, which in turn control FSH concentrations by negative feedback. At menopause, ovarian function and steroid secretion cease, causing FSH concentrations to rise due to a lack of negative feedback control. FSH concentrations are similarly raised in women of pre-menopausal age who suffer ovarian failure, or whose ovaries failed to mature during puberty. Elevated FSH concentrations are found in males when the testes have failed to develop to functional maturity, or, in cases of infertility due to primary testicular failure.