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Rheumatoid Factor, Quantative
MessagePerforming Lab: Central Lab
Test Code
3025
Alias/See Also
Sunquest: RFQ
CPT Codes
86431
Preferred Specimen
0.1 mL Serum (gold-top) tube
Minimum Volume
53 uL
Transport Temperature
Refrigerated
Specimen Stability
Room Temperature: 24 hours
Refrigerated: 72 hours
Frozen: 30 days
Refrigerated: 72 hours
Frozen: 30 days
Methodology
Immunoturbidimetric
Setup Schedule
Monday - Friday
Report Available
Same Day
Reference Range
0 - 30 IU/mL
Clinical Significance
Rheumatoid factor (RF) consists of autoantibodies of immunoglobulin isotypes IgM, IgA, IgG, and IgE. The function of RF remains unclear, but it may play a role in the regulation of humoral and cellular immunity and protection against invading microorganisms. Most patients with rheumatoid arthritis and Sjögren’s syndrome have elevated levels of RF. RF may also be elevated in scleroderma, dermatomyositis, Waldenström’s disease, sarcoidosis, and systemic lupus erythematosus. There are also instances of elevated RF without apparent disease or definable clinical disorders.