Progesterone

Message

Performing Lab: Central Lab

Test Code

0567

Alias/See Also

Sunquest: P4

CPT Codes
84144

Preferred Specimen

Specimen needs to be decanted
150 uL Gold Serum Separator Tube

Minimum Volume

150 uL

Other Acceptable Specimens

Lithium Heparin Plasma (light green-top) Tube

Instructions

Processing: Needs to be decanted after centrifugation.

Transport Temperature

Refrigerated

Specimen Stability

Refrigerated: 5 days
Frozen: 5 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Grossly hemolyzed

Methodology
Chemiluminescent Microparticle Immunoassay (CMIA)

Setup Schedule

Monday - Friday

Report Available

Same day

Reference Range

Females > 12 years:
Follicular: < 0.1 - 0.3 ng/mL
Luteal: 1.2 - 15.9 ng/mL
Postmenopausal: < 0.1 - 0.2 ng/mL

Pregnant Females:
1st Trimester (4-12 weeks) 2.8 - 147.3 ng/mL
2nd Trimester (13-24 weeks) 22.5 - 95.3 ng/mL
3rd Trimester (25-36 weeks) 27.9 - 242.5 ng/mL

Males: < 0.1 - 0.2 ng/mL

Clinical Significance

The main sites of progesterone production are the adrenal cortex, ovaries, and corpus luteum following ovulation and the placenta by the twelfth week of pregnancy. Circulating progesterone is bound to several serum proteins including albumin and corticosteroid binding globulin. The physiologically active free hormone represents approximately 3% of the total progesterone concentration. Measurement of serum progesterone is useful in the investigation of ovarian function where disorders of ovulation are responsible for infertility in 15–20% of patients, and for predicting ovulation in induced cycles, where concentrations are generally higher than normal. Properly timed measurements of progesterone can be used in the diagnosis of patients with recurrent and threatened abortion in the first ten weeks of gestation. Corpus luteum dysfunction is indicated by lower than normal progesterone concentrations.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.