Alkaline Phosphatase

Message

Performing Lab: Central Lab, Hudson, Lakeview, Regions, Sartell, Westfields

Test Code

0104

Alias/See Also

Sunquest: ALP

CPT Codes
84075

Preferred Specimen

0.1 mL Lithium Heparin Plasma (light green-top) tube

Minimum Volume

56 uL

Other Acceptable Specimens

Serum (gold-top) tube

Instructions

Processing:
Centrifuge specimens within 2 hours of collection

Transport Temperature

Refrigerated

Specimen Stability

Room Temperature: 4 days, Refrigerated: 7 days, Frozen: 3 months

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolyzed samples

Methodology

NADH without P-5'-P

Setup Schedule

Hospital: Daily
Clinics: Monday - Friday

Report Available

Same day

Reference Range

AGE	SEX	REFERENCE RANGE
>15 YRS	F	40-150
13-15 YRS	F	NONE
1-12 YRS	F	0-500
>20 YRS	M	40-150
16-20 YRS	M	NONE
12-15 YRS	M	0-750
1-11 YRS	M	0-500

Clinical Significance

Alkaline phosphatase is present mainly in bone, liver, kidney, intestine, placenta, and lung. Serum alkaline phosphatase may be elevated in increased bone metabolism, for example, in adolescents and during the healing of a fracture; primary and secondary hyperparathyroidism; Paget’s disease of bone; carcinoma metastatic to bone; osteogenic sarcoma; and Hodgkin’s disease if bones are invaded. Hepatobiliary diseases involving cholestasis, inflammation, or cirrhosis increase alkaline phosphatase activity; alkaline phosphatase activity may be increased in renal infarction and failure and in the complications of pregnancy. Low alkaline phosphatase activity may occasionally be seen in hypothyroidism.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.