Gamma Glutamyl Transferase (GGT)

Message

Performing Lab: Central Lab,St Cloud, Lakeview, Regions

Test Code

0496

Alias/See Also

Sunquest: GT; Gamma Glutamyl Transferase (Transpeptidase)

CPT Codes
82977

Preferred Specimen

100 uL Lithium Heparin Plasma (light green-top) tube

Minimum Volume

4 uL (does not include dead volume)

Other Acceptable Specimens

Serum separator (gold-top), Lithium Heparin (light green-top) on ICE, Red, Red/Gray

Transport Temperature

Refrigerated

Specimen Stability

Room Temperature: < 7 days
Refrigerated: < 7 days
Frozen: < 1 year at -20 C

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Grossly Hemolyzed or Grossly Icteric samples

Methodology
Multi-point Rate
L-Gamma-glutamyl-3-Carboxy-4-Nitroanilide Substrate

Setup Schedule

Hospital: Daily
Clinics: Monday - Friday

Report Available

Same day

Reference Range

Female: 9 - 36 U/L
Male: 12 - 64 U/L

Clinical Significance

Gamma Glutamyl transferase plays a major role in glutathione metabolism and in resorption of amino acids from the glomerular filtrate. It is also important in the absorption of amino acids from the intestinal lumen. GGT is found mainly in the liver, pancreas, and kidney, although lower activities can be demonstrated in most other organs.
Serum GGT is a sensitive indicator of hepatobiliary disease and is useful in the diagnosis of obstructive jaundice and chronic alcoholic liver disease, in the follow-up of chronic alcoholics undergoing treatment, and in the detection of hepatotoxicity. GGT is more responsive to biliary obstruction than AST, ALT, or ALKP. GGT is also increased in hepatoma, carcinoma of the pancreas, and carcinoma metastatic to the liver

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.